Leukotriene A4 hydrolase (LTA4H) is overexpressed in the early stages of rat and human esophageal adenocarcinomas (EAC), and its inhibition reduces the incidence of EAC in a rat model, according to a report in the July 16th Journal of the National Cancer Institute.

EAC, often preceded by gastroesophageal reflux (GERD), is "increasing at the most rapid rate of any cancer in the United States," the authors note.

"LTA4H overexpression appears to be an early event in esophageal adenocarcinogenesis and is a potential target for the chemoprevention of EAC," Dr. Yang and colleagues conclude.

"Recent studies of the crystal structure and molecular biology of LTA4H suggested that LTA4H epoxide hydrolase activity could be targeted efficiently and specifically by some potent LTA4H epoxide hydrolase inhibitors," they add. "We urge that future studies test the chemopreventive effects of these inhibitors on EAC."

posted by Cyndy | link | | |